to East Carolina University (Brody School of Medicine) from Alzheimer’s North Carolina for A Multidisciplinary Approach to Fight Senior Dementia: the Wooten Laboratory for Alzheimer’s and Neurodegenerative Diseases Research. Qun Lu, PhD
Grant History
to University of NC Wilmington, Department of Psychology for Research Project – Therapeutic Approaches to Regulate Neuroinflammation in Alzheimer’s Disease. Dr. Rachel Kohman
to Duke University from Alzheimer’s North Carolina for the Project – North Carolina Regional Consortium for Brain Health in Aging. Kathleen Welsh-Bohmer, PhD
to Brody School of Medicine East Carolina University from Alzheimer’s North Carolina for Part II of “A Multidisciplinary Approach to Fight Senior Dementia.” Qun Lu, PhD
to Harriet & John Wooten Laboratory for Alzheimer’s and Neurodegenerative Diseases. Qun Lu, PhD
to Harriet & John Wooten Laboratory for Alzheimer’s and Neurodegenerative Diseases. Qun Lu, PhD
Two winners of the Lina Mae Edwards Young Investigator Research Grants:
Jessica M. Ellis, PhD, East Carolina University: Deciphering the Role of DHA in the Development of Brain Disorders
Daniel Parker, MD, Duke University: The Effect of Exercise Mode, Amount and Intensity on Plasma Markers of Brain Aging in Healthy Adults.
Two winners of the Lina Mae Edwards Young Investigator Research Grants:
Milta Oyola Little, D.O., Associate Professor of Geriatric Medicine at Duke University: Implementation of Cognitive Stimulation Therapy
Dr. Shivani Ghoshal Assistant Professor of Neurology with Wake Forest University: Impact of TCD Cerebral Hemodynamics During Dialysis on Cognitive Decline and Cerebral Structural Change
Dementia Alliance of North Carolina is pleased to announce the winner of the 2021 Lina Mae Edwards Young Investigator Research Grants. James R. Bateman, MD, MPH, of Wake Forest University Health Sciences will be awarded $100,000 for his project titled “Autonomic Biomarkers of Mild Behavioral Impairment in ADRD.”
Dementia Alliance of North Carolina’s Lina Mae Edwards Young Investigator Research Grant Announced! Dr. Giulia Fragola, Research Associate in Dr. Todd Cohen’s lab in the UNC Department of Neurology, has been awarded $100,000 for the 2022 Lina Mae Edwards Young Investigator Award by Dementia Alliance of North Carolina for her project entitled “Tau depletion via CRISPR/Cas technology as a therapy for Alzheimer’s Disease.”
Erica Frechman, PhD, Assistant Professor of Internal Medicine, section on Gerontology and Geriatric Medicine at Wake Forest University School of Medicine has been awarded $100,000 for the 2023 Lina Mae Edwards Young Investigator Award by Dementia Alliance of North Carolina (DA-NC). The DA-NC research program aims to tackle vital issues in dementia science and caregiver support, including understanding causes, prevention, and cures, as well as enhancing the lives of individuals with dementia and supporting their families.
Dementia Alliance annually awards the Lina Mae Edwards Young Investigator Research Grant to early career scientists and researchers in North Carolina who are focusing on studying issues related to dementia care, treatment, and disease understanding and prevention.
The Lina Mae Edwards Young Investigator Research Grant is made possible by our generous partners Guardian Angel Thrift and together we are thrilled to announce the 2024 recipient – Dr. Frances Mead Bashore!
Dr. Bashore is a Research Assistant Professor at the University of North Carolina at Chapel Hill. Her funded project is dedicated to development of proteolysis targeting chimeras (PROTACs) that target the Thousand and One Kinases (TAOK) family for degradation, and evaluation of their impact on tau phosphorylation.
Alzheimer’s disease (AD) pathology is driven, in part, by the accumulation of tau protein in the brain as tangles. The formation of tau tangles is accelerated through the activity of a group of enzymes known as Thousand And One Kinases (TAOKs). To slow or prevent the activity of the TAOKs, Dr. Bashore’s research project will design and synthesize a class of molecules that harness the ability of the body to clear unwanted proteins via degradation. Dr. Bashore’s project will determine if these molecules, called PROTACs, are more effective than available inhibitors of TAOKs, and represent pre-clinical candidates in the AD pipeline.